Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was found in diverse epithelial and immune cell types, accompanied by dramatic transcriptomic changes within virus-positive cells.
The large dataset enabled us to identify that different peripheral immune subtype changes are associated with distinct clinical features, including age, sex, severity, and disease stages of COVID-19. We applied single-cell RNA sequencing to 284 samples from 196 COVID-19 patients and controls and created a comprehensive immune landscape with 1.46 million cells. Xianwen Ren, 1, 40 Wen Wen, 2, 3, 4, 40 Xiaoying Fan, 5, 11, 40 Wenhong Hou, 6, 40 Bin Su, 7, 40 Pengfei Cai, 8, 40 Jiesheng Li, 1, 40 Yang Liu, 9, 40 Fei Tang, 1, 40 Fan Zhang, 10, 40 Yu Yang, 1, 40 Jiangping He, 5, 40 Wenji Ma, 11, 40 Jingjing He, 12, 40 Pingping Wang, 13, 40 Qiqi Cao, 2, 3, 4 Fangjin Chen, 34 Yuqing Chen, 1 Xuelian Cheng, 14, 15 Guohong Deng, 16 Xilong Deng, 20 Wenyu Ding, 11, 17 Yingmei Feng, 7 Rui Gan, 10 Chuang Guo, 8 Weiqiang Guo, 37 Shuai He, 12 Chen Jiang, 8 Juanran Liang, 19 Yi-min Li, 21 Jun Lin, 8 Yun Ling, 23 Haofei Liu, 24 Jianwei Liu, 5 Nianping Liu, 8 Shu-Qiang Liu, 12 Meng Luo, 13 Qiang Ma, 11 Qibing Song, 25 Wujianan Sun, 8 GaoXiang Wang, 26 Feng Wang, 27 Ying Wang, 27 Xiaofeng Wen, 19 Qian Wu, 17 Gang Xu, 9 Xiaowei Xie, 14, 15 Xinxin Xiong, 12 Xudong Xing, 28 Hao Xu, 8 Chonghai Yin, 11 Dongdong Yu, 25 Kezhuo Yu, 1 Jin Yuan, 9 Biao Zhang, 14, 15 Peipei Zhang, 24, 38, 39, 40 Tong Zhang, 7 Jincun Zhao, 21 Peidong Zhao, 18 Jianfeng Zhou, 26 Wei Zhou, 5 Sujuan Zhong, 17 Xiaosong Zhong, 35 Shuye Zhang, 36 Lin Zhu, 8 Ping Zhu, 14, 15 Bin Zou, 19 Jiahua Zou, 29 Zengtao Zuo, 11 Fan Bai, 1 Xi Huang, 30 Penghui Zhou, 12, ∗ Qinghua Jiang, 13, ∗∗ Zhiwei Huang, 10, ∗∗∗ Jin-Xin Bei, 12, ∗∗∗∗ Lai Wei, 19, ∗∗∗∗∗ Xiu-Wu Bian, 24, 38, ∗∗∗∗∗∗ Xindong Liu, 24, 38, ∗∗∗∗∗∗∗ Tao Cheng, 14, 15, ∗∗∗∗∗∗∗∗ Xiangpan Li, 31, ∗∗∗∗∗∗∗∗∗ Pingsen Zhao, 32, 33, ∗∗∗∗∗∗∗∗∗∗ Fu-Sheng Wang, 28, ∗∗∗∗∗∗∗∗∗∗∗ Hongyang Wang, 2, 3, 4, ∗∗∗∗∗∗∗∗∗∗∗∗ Bing Su, 27, ∗∗∗∗∗∗∗∗∗∗∗∗∗ Zheng Zhang, 9, ∗∗∗∗∗∗∗∗∗∗∗∗∗∗ Kun Qu, 8, ∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗ Xiaoqun Wang, 5, 11, ∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗ Jiekai Chen, 5, 22, ∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗ Ronghua Jin, 7, ∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗ and Zemin Zhang 1, 6, 41, ∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗∗Ī dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent immune cells is not complete.
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